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pentobarbital will lessen the extent or effect of abemaciclib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Coadministration of abemaciclib with strong CYP3A4 inducers lessens plasma concentration of abemaciclib and its metabolites.Even though it can be employed to be a sedative and anticonvulsant by physi